Chondroitin Sulfates in Axon Regeneration and Plasticity
نویسندگان
چکیده
منابع مشابه
Kindlin-1 enhances axon growth on inhibitory chondroitin sulfate proteoglycans and promotes sensory axon regeneration.
Growing and regenerating axons need to interact with the molecules in the extracellular matrix as they traverse through their environment. An important group of receptors that serve this function is the integrin superfamily of cell surface receptors, which are evolutionarily conserved αβ heterodimeric transmembrane proteins. The function of integrins is controlled by regulating the affinity for...
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It is essential to establish a library of glycosaminoglycan oligosaccharides from the chondroitin and dermatan sulfates to investigate their biological functions and structure-activity relationships (SARs). There are several approaches to obtain oligosaccharides using chemical and enzymatic degradation procedures; however, purification of each resulting oligosaccharide is complicated because of...
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Polysaccharides (variously called as glycanes or polyholosides or polyosides) are high molecular weight carbohydrates which, on hydrolysis, yield mainly monosaccharides or products related to monosaccharides. They may also be regarded as polymeric anhydrides of simple sugars. D-glucose is the commonest component of polysaccharides. However, D-and L-galactose, D-mannose, D-xylose, L-arabinose as...
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PURPOSE OF REVIEW The inflammatory response that accompanies neural injury involves multiple cell types and effector molecules with both positive and negative effects. Inflammation is essential for normal regeneration in the peripheral nervous system, and here we review evidence that augmenting inflammation can enhance regeneration in areas of the central nervous system in which it normally doe...
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Nogo-A is one of several neurite growth inhibitory components present in oligodendrocytes and CNS myelin membranes. Nogo has a crucial role in restricting axonal regeneration and compensatory fibre growth in the injured adult mammalian CNS. Recent studies have shown that in vivo applications of Nogo neutralizing antibodies, peptides blocking the Nogo receptor subunit NgR, or blockers of the pos...
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ژورنال
عنوان ژورنال: Trends in Glycoscience and Glycotechnology
سال: 2011
ISSN: 0915-7352,1883-2113
DOI: 10.4052/tigg.23.201